27 maart 2018

Bayer, Exeter University and Rothamsted Research to identify enzymes in bees that determine sensitivity to neonicotinoids

Monheim, March 22, 2018 – A joint study by Exeter University, Rothamsted Research and Bayer has discovered enzymes in honey bees and bumble bees that determine how sensitive they are to different neonicotinoid insecticides.

As in other organisms, toxins in bees can be broken down by enzymes called cytochrome P450s. The researchers carried out the most comprehensive analysis of bee P450 detoxification enzymes ever conducted. The study identified one subfamily of these enzymes in bees – CYP9Q – and found it was responsible for the rapid breakdown of certain neonicotinoids, such as thiacloprid, making them virtually non-toxic to bees. Bayer is confident that this knowledge will enable the company to design further bee-friendly insecticides in an even more targeted way, using relatively simple methods (in vitro) at an early stage of a product’s development.

“Identifying the mechanisms that contribute to inherent tolerance helps us, and regulators, to better understand why certain insecticides have a high margin of safety in bees,” said Dr. Ralf Nauen, an insect toxicologist at Bayer and lead investigator of the study. “The knowledge from our study can also be used to predict and prevent potential harmful effects that result from inadvertently blocking these key defence systems, for instance, by different compounds with synergistic effects in tank mixtures.” Nauen is confident that the required knowledge and obtained tools will promote innovation and improve Bayer’s ability to develop selective insecticides.

The paper, published in the journal Current Biology, is entitled: “Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides.”

This knowledge is valuable at a time when it has become increasingly difficult to register new pesticides, particularly in Europe, a development which will ultimately hurt farmers, preventing them from controlling the pests attacking their fields and producing the food we all enjoy. The sad thing is that, likewise, the environment will suffer as less efficient production requires more land use.

Safety before sales applies to all pesticides brought to market. Nonetheless, the safety of neonicotinoid insecticides to bees is a controversially discussed subject and one that, in 2013, led to a ban in the European Union on the use of three compounds on crops that are attractive to bees. So what does the science say? In general, that 19 of the top 20 insecticides are intrinsically highly toxic. However, even the different compounds in the class of neonicotinoids vary in terms of their toxicity.

By the time it reaches the market, each crop protection product will have cost, on average, USD 286 million and required 11 years of research and development to ensure the highest safety and efficacy standards. This new knowledge will help to make the development of insecticides, which are broadly applicable and fully compatible with bee pollinators, more efficient.

About Bayer
Bayer is a global enterprise with core competencies in the Life Science fields of health care and agriculture. Its products and services are designed to benefit people and improve their quality of life. At the same time, the Group aims to create value through innovation, growth and high earning power. Bayer is committed to the principles of sustainable development and to its social and ethical responsibilities as a corporate citizen. In fiscal 2017, the Group employed around 99,800 people and had sales of EUR 35.0 billion. Capital expenditures amounted to EUR 2.4 billion, R&D expenses to EUR 4.5 billion. For more information, go to www.bayer.com.

Note to editors:
A print-quality photo can be downloaded from our website at www.news.bayer.com.

Utz Klages, phone +49 2173 38-3125
Email: utz.klages@bayer.com

Find more information at www.bayer.com.

kgs (2018-0086)

Forward-Looking Statements 
This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer’s public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.